MICROANATOMY

Detailed explanation-1: -Memory B cells persist after antigen challenge, rapidly expand during secondary responses, and can terminally differentiate into antibody-secreting plasma cells.

Detailed explanation-2: -Normally, hematopoietic stem cells, within the bone marrow mature into a common lymphoid progenitor cell, which then becomes either a B-cell or a T-cell.

Detailed explanation-3: -Upon stimulation by a T cell, which usually occurs in germinal centers of secondary lymphoid organs such as the spleen and lymph nodes, the activated B cell begins to differentiate into more specialized cells. Germinal center B cells may differentiate into memory B cells or plasma cells.

Detailed explanation-4: -plasma cell, short-lived antibody-producing cell derived from a type of leukocyte (white blood cell) called a B cell. B cells differentiate into plasma cells that produce antibody molecules closely modeled after the receptors of the precursor B cell.