MICROANATOMY

Detailed explanation-1: -Antigens and dendritic cells (DCs) reach the draining lymph node through afferent lymphatic vessels; they must then enter the lymph node and migrate deep into it to activate T cells. Lymph nodes are enclosed in a collagen-rich capsule, which is underlined with lymphatic endothelial cells forming the subcapsular sinus.

Detailed explanation-2: -The lymph node is the first place that immune cells encounter blood-borne antigens. The spleen is classically considered an organ that “filters” antigens from blood. The lymph node receives antigens principally from the afferent lymphatics.