DIGESTIVE SYSTEM
LIVER
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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using ethanol dehydrogenase
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converted to hydrophobic substances
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converted to hydrophilic substances
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converted to urea
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Detailed explanation-1: -First, ADH metabolizes alcohol to acetaldehyde, a highly toxic substance and known carcinogen (1). Then, in a second step, acetaldehyde is further metabolized down to another, less active byproduct called acetate (1), which then is broken down into water and carbon dioxide for easy elimination (2).
Detailed explanation-2: -The liver is the primary organ responsible for the detoxification of alcohol. Liver cells produce the enzyme alcohol dehydrogenase which breaks alcohol into ketones at a rate of about 0.015 g/100mL/hour (reduces BAC by 0.015 per hour).
Detailed explanation-3: -Alcohol dehydrogenase (ADH) and mitochondrial aldehyde dehydrogenase (ALDH2) are responsible for metabolizing the bulk of ethanol consumed as part of the diet and their activities contribute to the rate of ethanol elimination from the blood.