MICROANATOMY

Detailed explanation-1: -Gallstones are a common cause of pancreatitis. Gallstones, produced in the gallbladder, can slip out of the gallbladder and block the bile duct, stopping pancreatic enzymes from traveling to the small intestine and forcing them back into the pancreas.

Detailed explanation-2: -Gallstone-induced pancreatitis is caused by duct obstruction by gallstone migration. Obstruction is localized in the bile duct and pancreatic duct, or both. Duct obstruction promotes pancreatitis by increasing duct pressure and subsequent unregulated activation of digestive enzymes[9].

Detailed explanation-3: -The two main causes of acute pancreatitis are gallstones and alcohol, accounting for more than 80% of acute pancreatitis. Removal of the gallbladder (cholecystectomy) is the definitive treatment for prevention of further attacks of acute gallstone pancreatitis if the person is suitable for surgery.