MICROANATOMY

Detailed explanation-1: -pancreatic polypeptide, peptide secreted by the F (or PP) cells of the islets of Langerhans in the pancreas. Pancreatic polypeptide contains 36 amino acids. Its secretion is stimulated by eating, exercising, and fasting.

Detailed explanation-2: -Pancreatic Polypeptide (PP) is a 36 amino acid peptide produced and secreted by PP cells (originally termed F cells) of the pancreas which are primarily located in the Islets of Langerhans. It is part of a family of peptides that also includes Peptide YY (PYY) and Neuropeptide Y (NPY).

Detailed explanation-3: -Islets largely (up to 70%) consist of B cells which secrete the hormone insulin and are located centrally within the islet. In comparison, F cells constitute approximately 15% of islet cell mass and secrete the hormone pancreatic polypeptide (PP).

Detailed explanation-4: -Pancreatic polypeptide (PP), 36-amino acid peptide, may function as an important feedback inhibitor of pancreatic secretion after a meal. It arises from both islet and acinar cells of the pancreas. Release of PP by a meal, primarily protein, occurs in a biphasic manner.