MICROANATOMY

Detailed explanation-1: -Pancreatic –cells secrete the hormone somatostatin (SST). –cells are also present in the hypothalamus, central nervous system (CNS), peripheral neurons and the gastrointestinal tract (Arimura et al.

Detailed explanation-2: -OBJECTIVE-Somatostatin (SST) is secreted by islet -cells and by extraislet neuroendocrine cells. SST receptors have been identified on -and -cells, and exogenous SST inhibits insulin and glucagon secretion, consistent with a role for SST in regulating -and -cell function.

Detailed explanation-3: -The delta cells produce somatostatin, a strong inhibitor of somatotropin, insulin, and glucagon; its role in metabolic regulation is not yet clear. Somatostatin is also produced by the hypothalamus and functions there to inhibit secretion of growth hormone by the pituitary gland.

Detailed explanation-4: -Somatostatin from the hypothalamus inhibits the pituitary gland’s secretion of growth hormone and thyroid stimulating hormone. In addition, somatostatin is produced in the pancreas and inhibits the secretion of other pancreatic hormones such as insulin and glucagon.