MICROANATOMY

Detailed explanation-1: -The release of aldosterone from the adrenal glands is regulated via the renin-angiotensin II-aldosterone system. This system is initially activated via a decrease in the mean arterial blood pressure to increase the blood pressure.

Detailed explanation-2: -Aldosterone is a steroid hormone synthesized in and secreted from the outer layer of the adrenal cortex, the zona glomerulosa. Aldosterone is responsible for regulating sodium homeostasis, thereby helping to control blood volume and blood pressure.

Detailed explanation-3: -The zona glomerulosa (ZG) is the most superficial layer of the adrenal cortex and it produces the hormone aldosterone as well as some small amounts of progesterone (a sex hormone). The mineralocorticoid aldosterone is produced here.

Detailed explanation-4: -Five classes of steroid hormones are produced in the adrenal cortex: glucocorticoids, mineralocorticoids, progestins, androgens, and estrogens. However, the amount of progestin, androgen, and estrogen produced by the adrenal is a minor fraction of the total amount of these steroids produced in the body.

Detailed explanation-5: -Aldosterone is synthesized in the zona glomerulosa of the adrenal gland. It regulates electrolyte excretion and intravascular volume mainly through its effects on the distal tubules and cortical collecting ducts of the kidneys in which it acts to increase sodium reabsorption and potassium excretion.