MICROANATOMY

Detailed explanation-1: -Pathophysiology. Antidiuretic hormone (ADH) induces water retention by increasing the permeability of nephrons. Its influence on water permeability occurs primarily by regulating aquaporin 2 water channels in the distal tubules and collecting ducts of the kidney (Kwon et al., 2001).

Detailed explanation-2: -High levels of anti-diuretic hormone cause the kidneys to retain water in the body.

Detailed explanation-3: -ADH primarily affects the ability of the kidney to reabsorb water; when present, ADH induces expression of water transport proteins in the late distal tubule and collecting duct to increase water reabsorption. Several disease states arise when the body loses control of ADH secretion or responds to its presence.

Detailed explanation-4: -Normal ADH levels in adults vary but are usually less than 2.5 pg/mL. Higher than normal results may mean that you have a condition called syndrome of inappropriate antidiuretic hormone (SIADH). It causes your body to hold onto too much water instead of getting rid of it in your urine.