MICROANATOMY

Detailed explanation-1: -Steroid Hormone Receptors (SHR) act as hormone dependent nuclear transcription factors. Upon entering the cell by passive diffusion, the hormone (H) binds the receptor, which is subsequently released from heat shock proteins, and translocates to the nucleus.

Detailed explanation-2: -Steroid hormones bind receptors in the cell nucleus and in the cell membrane. The most widely studied class of steroid hormone receptors are the nuclear receptors, named for their function as ligand-dependent transcription factors in the cell nucleus.

Detailed explanation-3: -Steroid hormone receptors are found in the nucleus, cytosol, and also on the plasma membrane of target cells. They are generally intracellular receptors (typically cytoplasmic or nuclear) and initiate signal transduction for steroid hormones which lead to changes in gene expression over a time period of hours to days.

Detailed explanation-4: -They are lipid soluble, which facilitates their transport through the cell membrane. In the cytoplasm, steroid hormones bind to receptors that form homodimers or heterodimers, migrate to the nucleus, and function as nuclear receptors and transcription factors.

Detailed explanation-5: -When a steroid hormone enters the cell, the nuclear hormone receptor binds the hormone and dissociates from the HSP. The receptors, then, with the hormone bound, translocate into the nucleus.