MICROANATOMY

Detailed explanation-1: -Calcitonin inhibits (blocks) the activity of osteoclasts, which are cells that break down bone. When osteoclasts break down your bone, the calcium from your bone is released into your bloodstream. Therefore, the temporary blocking of osteoclasts by calcitonin reduces the amount of calcium that enters your blood.

Detailed explanation-2: -Calcitonin reduces calcium levels in the blood by two main mechanisms: It inhibits the activity of osteoclasts, which are the cells responsible for breaking down bone. When bone is broken down, the calcium contained in the bone is released into the bloodstream.

Detailed explanation-3: -Calcitonin and bone It has been postulated that CT acts postprandially to use phosphate to store calcium in bone [21, 66].

Detailed explanation-4: -Calcitonin – For immediate, short-term management of hypercalcemia in symptomatic patients (eg, lethargy, stupor) with calcium >14 mg/dL (3.5 mmol/L), we suggest administration of calcitonin (Grade 2C). Calcitonin is used in combination with saline hydration and bisphosphonates.