MICROANATOMY

Detailed explanation-1: -Cushing disease occurs when a pituitary adenoma, a noncancerous (benign) tumor on the pea-size pituitary gland, makes too much adrenocorticotropic hormone (ACTH). In response, the body’s two adrenal glands, one atop each kidney, make too much cortisol.

Detailed explanation-2: -A noncancerous (benign) tumor of the pituitary gland, located at the base of the brain, produces an excess amount of ACTH, which in turn stimulates the adrenal glands to make more cortisol. When this form of the syndrome develops, it’s called Cushing disease.

Detailed explanation-3: -The most common cause of Cushing’s syndrome is the long-term, high-dose use of the cortisol-like glucocorticoids. These medicines are used to treat other medical conditions, such as asthma link, rheumatoid arthritis link, and lupus link. Glucocorticoids are often injected into a joint to treat pain.

Detailed explanation-4: -Cushing’s syndrome is a disorder caused by the body’s exposure to an excess of the hormone cortisol. Cortisol affects all tissues and organs in the body. These effects together are known as Cushing’s syndrome.

Detailed explanation-5: -Exogenous Cushing syndrome occurs when a person takes man-made (synthetic) glucocorticoid medicines to treat a disease. These medicines act like cortisol in the body. Glucocorticoids are given for many diseases, such as lung diseases, skin conditions, inflammatory bowel disease, cancer, brain tumors, and joint disease.