MICROANATOMY

Detailed explanation-1: -Moreover, glucocorticoids modulate the function of pancreatic and cells to regulate the secretion of glucagon and insulin, two hormones that play a pivotal role in the regulation of blood glucose levels.

Detailed explanation-2: -Glucagon is a hormone that your pancreas makes to help regulate your blood glucose (sugar) levels. Glucagon increases your blood sugar level and prevents it from dropping too low, whereas insulin, another hormone, decreases blood sugar levels.

Detailed explanation-3: -The adrenocorticotropic hormone (ACTH) from the pituitary gland activates the adrenal cortex to release glucocorticoids in response to stress. The adrenal cortex also produces androgens: hormones responsible for the development of male characteristics.

Detailed explanation-4: -Glucocorticoids also induce insulin resistance, hyperglycemia, and hyperlipidemia. While increases in visceral fat contribute to the insulin resistance that occurs with glucocorticoid therapy, direct actions of glucocorticoids on muscle, liver, and other tissues also play a role.