MICROANATOMY

Detailed explanation-1: -Steroid hormones and thyroid hormone are lipid soluble. All other amino acid–derived hormones are water soluble. Hydrophobic hormones are able to diffuse through the membrane and interact with an intracellular receptor. In contrast, hydrophilic hormones must interact with cell membrane receptors.

Detailed explanation-2: -Lipid-derived (soluble) hormones can enter the cell by diffusing across the plasma membrane and binding to DNA to regulate gene transcription and to change the cell’s activities by inducing production of proteins that affect, in general, the long-term structure and function of the cell.

Detailed explanation-3: -Steroid hormones are the most common circulating lipid-soluble hormones. Steroid hormones include: testosterone, estrogens, progesterone, aldosterone and cortisol.