MICROANATOMY

Detailed explanation-1: -Most often, the cause is a benign tumor of the parathyroid glands (parathyroid adenoma). These benign tumors are common and happen without a known cause. The disease is most common in people over age 60, but it can also occur in younger adults. Hyperparathyroidism in childhood is very unusual.

Detailed explanation-2: -In primary hyperparathyroidism, serum phosphate levels are often low because of the phosphaturic effects of parathyroid hormone. Serum phosphate levels may also be low in the presence of a malignant growth that secretes ectopic parathyroid hormone or parathyroid-related peptide.

Detailed explanation-3: -Serum phosphate levels are high in primary and secondary hyperparathyroidism and low in primary hyperparathyroidism due to increased renal phosphate excretion.

Detailed explanation-4: -What happens if I have too much parathyroid hormone? A primary problem in the parathyroid glands, producing too much parathyroid hormone causes raised calcium levels in the blood (hypercalcaemia) and this is referred to as primary hyperparathyroidism.