MICROANATOMY

Detailed explanation-1: -Blood tests that measure the hormones T-4 and T-3 and thyroid-stimulating hormone (TSH) can confirm a diagnosis of hyperthyroidism. A high level of T-4 and a low level of TSH is common in people with hyperthyroidism.

Detailed explanation-2: -Conclusion: The calcium:creatinine clearance ratio (CCCR) is the consensus biochemical test to differentiate between PHPT and FHH. However, this test is still limited by a considerable indeterminate range, and definitive diagnosis of FHH requires genetic testing.

Detailed explanation-3: -FHH is biologically characterized by moderate but significant hypercalcemia associated with levels of PTH and urinary calcium excretion that appear inappropriate in the presence of the hypercalcemia: serum levels of PTH are, in general, normal or slightly increased and calciuria is low.

Detailed explanation-4: -It has been reported that hyperthyroidism is associated with mild to moderate hypercalcemia in approximately 20% of total patients. The serum calcium levels are often increased by a mild to moderate range and it rarely exceeds 3.0 mmol/L in hyperthyroidism associated hypercalcemia.