MICROANATOMY

Detailed explanation-1: -Since parathyroid hormone is a key calcium-regulating hormone essential for calcium homeostasis, metabolic dysfunction in hypoparathyroidism originate hyperphosphatemia and consequently elevated serum calcium-phosphorus product, resulting in ectopic soft tissue calcifications.

Detailed explanation-2: -The most common cause of hypoparathyroidism is injury to the parathyroid glands during thyroid or neck surgery. It may also be caused by any of the following: Autoimmune attack on the parathyroid glands (common) Very low magnesium level in the blood (reversible)

Detailed explanation-3: -Dystrophic calcifications of secondary hyperparathyroidism are typically seen in the basal ganglia, the thalami, periventricular white matter, cerebellum, and sometimes the cortex. The cause of the deposition is not entirely known.

Detailed explanation-4: -Untreated or undertreated hypoparathyroidism can lead to complications, including problems with the eyes, kidneys, and heart, stunted growth and slowed mental development in children, and calcium deposits in the brain, which can cause frequent seizures and balance problems.