MICROANATOMY

Detailed explanation-1: -Triiodothyronine (T3), the active form of thyroid hormone is produced predominantly outside the thyroid parenchyma secondary to peripheral tissue deiodination of thyroxine (T4), with <20% being secreted directly from the thyroid.

Detailed explanation-2: -This is because cells that have receptors that receive the effect of thyroid hormone are better able to use T3 than T4. Therefore, T4 is generally considered to be the inactive form of thyroid hormone, and T3 is considered the active form of it.

Detailed explanation-3: -T3 is the active form of thyroid hormone, meaning it impacts cells in your body, whereas T4 is the inactive form of thyroid hormone. Your liver and kidneys convert most of the T4 your thyroid releases into T3.

Detailed explanation-4: -The thyroid produces approximately 90% inactive thyroid hormone, or thyroxine (T4), and 10% active thyroid hormone, or triiodothyronine (T3).

Detailed explanation-5: -Context. The two major forms of circulating thyroid hormones (THs) are T3 and T4. T3 is regarded as the biologically active hormone because it binds to TH receptors (TRs) with greater affinity than T4.