ENDOCRINE ORGANS AND RESPIRATORY SYSTEM
THYROID
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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Tetraiodothyronine (T4) is converted to triiodothyronine (T3) in the periphery by all of the following deiodinases except ____
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D1
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D2
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D3
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it is converted by all of these deiodinases
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Explanation:
Detailed explanation-1: -T4 is converted into T3, the active form of thyroid hormone, by two enzymes called deiodinases.
Detailed explanation-2: -DIO3 catalyzes the conversion of T4 to rT3 and T3 to 3, 3′-diiodothyronine (T2), both of which are biologically inactive. DIO3 is the main deiodinase during the embryonic period and in developing tissues, protecting developing tissues from excessive TH production.
Detailed explanation-3: -Deiodinases expressed in peripheral tissues remove iodine from thyroid hormones, converting T4 to T3, an important action in increasing hormone potency, and further removing iodine to inactivate the hormones completely.
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