MICROANATOMY

Detailed explanation-1: -Osteoclasts are the cells that degrade bone to initiate normal bone remodeling and mediate bone loss in pathologic conditions by increasing their resorptive activity.

Detailed explanation-2: -The area of the osteoclast next to bone forms a “ruffled border” consisting of multiple infoldings of the osteoclast cell membrane. It secretes acid and proteases across the ruffled border, and these dissolve the mineral of bone and destroy the organic matrix (see Figure 9.8.