MICROANATOMY

Detailed explanation-1: -Interleukin 4 (also known as “B cell stimulatory factor-1"), a cytokine product of T lymphocytes and mast cells, stimulates synthesis of the extracellular matrix proteins, types I and III collagen and fibronectin, by human dermal fibroblasts in vitro.

Detailed explanation-2: -Fibroblasts are developmentally programmed to produce collagen matrix, which is the main structural component of connective tissue. Fibroblasts have cell surface receptors, called integrins, which specifically attach to proteins in the matrix including type I collagen.

Detailed explanation-3: -Fibroblasts are ubiquitous mesenchymal cells which synthesize collagen and other matrix macromolecules for the structural support of connective tissues. They are important in wound repair but also contribute connective tissue proteins to areas of chronic inflammation.

Detailed explanation-4: -Significance: Fibroblasts play a critical role in normal wound healing. Various extracellular matrix (ECM) components, including collagens, fibrin, fibronectin, proteoglycans, glycosaminoglycans, and matricellular proteins, can be considered potent protagonists of fibroblast survival, migration, and metabolism.