MICROANATOMY

Detailed explanation-1: -Corneodesmosomes are modified desmosomes present in the stratum corneum (SC). They are crucial for SC cohesion and, thus, constitute one of the pivotal elements of the functional protective barrier of human skin.

Detailed explanation-2: -Corneodesmosomes are the main intercellular adhesive structures in the stratum corneum. They are transformed from desmosomes at the most superficial layer of the stratum granulosum of the epidermis. The major compositional distinction from desmosomes is the presence of corneodesmosin in the extracellular portion.

Detailed explanation-3: -The stratum spinosum (or spinous layer/prickle cell layer) is a layer of the epidermis found between the stratum granulosum and stratum basale. This layer is composed of polyhedral keratinocytes. These are joined with desmosomes.

Detailed explanation-4: -The function of desmosomes is to adhere cells together. They are found in high numbers in tissues that are subject to a lot of mechanical forces. For example, many are found in the epidermis, which is the outer layer of skin, and the myocardium, which is muscle tissue in the heart.

Detailed explanation-5: -Desmosomes are found subjacent to the AJs and are more widely distributed along the lateral membranes. By tethering the intermediate filament (IF) cytoskeleton to the plasma membrane, these strongly adhesive junctions further enhance their force-resisting mechanical properties (see Poster, panels 1 and 3).