MICROANATOMY

Detailed explanation-1: -The squamous cell layer is the thickest layer of the epidermis, and is involved in the transfer of certain substances in and out of the body. The squamous cell layer also contains cells called Langerhans cells.

Detailed explanation-2: -Langerhans cells are normally found scattered among keratinocytes of the stratum spinosum. They constitute 3%–5% of the cells in this layer. As with melanocytes, Langerhans cells are not connected to adjacent keratinocytes by the desmosomes.

Detailed explanation-3: -Langerhans cells (LCs) were first described by Paul Langerhans, in 1868, as dendritically shaped cells, which were located in the squamous epithelia of epidermis.

Detailed explanation-4: -Stratum spinosum, 8-10 cell layers, also known as the prickle cell layer contains irregular, polyhedral cells with cytoplasmic processes, sometimes called “spines”, that extend outward and contact neighboring cells by desmosomes. Dendritic cells can be found in this layer.