MICROANATOMY

Detailed explanation-1: -Mast Cells: Mast cells rapidly degranulate upon crosslinking of specific IgE by corresponding allergens and release preformed histamine, proteases (chymase, tryptase) and cytokines (TNF-alpha), followed by the rapid synthesis and release of prostaglandins and leukotrienes.

Detailed explanation-2: -Share this page: Mast cells are allergy cells responsible for immediate allergic reactions. They cause allergic symptoms by releasing products called “mediators” stored inside them or made by them.

Detailed explanation-3: -Mast cells and basophils represent the most relevant source of histamine in the immune system. Histamine is stored in cytoplasmic granules along with other amines (e.g., serotonin), proteases, proteoglycans, cytokines/chemokines, and angiogenic factors and rapidly released upon triggering with a variety of stimuli.

Detailed explanation-4: -When mast cells detect a substance that triggers an allergic reaction (an allergen), they release histamine and other chemicals into the bloodstream. Histamine makes the blood vessels expand and the surrounding skin itchy and swollen.

Detailed explanation-5: -The IgE-primed mast cell releases granules and powerful chemical mediators, such as histamine, cytokines, granulocyte macrophage colony-stimulating factor (GM-CSF), leukotrienes, heparin, and many proteases into the environment. These chemical mediators cause the characteristic symptoms of allergy.