MICROANATOMY

Detailed explanation-1: -Brain microtubule assembly may be inhibited by non-brain factors such as plant alkaloids like vinblastine (see above) or by polyanions such as RNA (Bryan, Nagle and Doenges, 1975).

Detailed explanation-2: -Microtubule inhibitors (MTI) include agents such as taxanes, vinca alkaloids, and epothilones that are used against many solid and hematologic malignancies. Although MTIs have significant clinical activity in multiple tumor types, their effectiveness is reduced by drug resistance mechanisms.

Detailed explanation-3: -The inhibition of microtubule function by MTAs causes inhibition of the AKT/mTOR signaling pathway and thus inhibits cancer cell proliferation. This mechanism is independent of MTAs induced mitotic arrest and could provide an alternative mechanism of drug action that can explain its clinical activity.