INTRODUCTION TO MICROSCOPY CELL BIOLOGY
CYTOSKELETON
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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The end of a growing microtubule is rich in which type of tubulin?
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GTP bound tubulin molecules
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GDP bound molecules
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ATP bound tubulin
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ADP bound molecules
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Explanation:
Detailed explanation-1: -Because GMPCPP strongly promotes spontaneous nucleation of microtubules, we propose that GTP hydrolysis by tubulin also plays the important biological role of inhibiting spontaneous microtubule nucleation.
Detailed explanation-2: -Tubulin is an / heterodimer. Both -and -tubulins are GTP-binding proteins; -tubulin binds GTP nonexchangeably, whereas the GTP-binding site on -tubulin is exchangeable (1).
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