INTRODUCTION TO MICROSCOPY CELL BIOLOGY
CYTOSKELETON
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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Cytochalasin B
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Cochicine
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Aspirin
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All
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Detailed explanation-1: -Abstract. Substoichiometric cytochalasin B (CB) inhibits both the rate of actin polymerization and the interaction of actin filaments in solution. The polymerization rate is reduced by inhibition of actin monomer addition to the “barbed” end of the filaments where monomers normally add more rapidly.
Detailed explanation-2: -Inhibits cell division Cytochalasin B is used for testing of the genotoxicity of substances. In order to do so, cytokinesis-block micronucleus assay (CBMN assay) with human lymphocytes is applied. This works in vitro. During anaphase of mitosis of meiosis, micronuclei can be detected.
Detailed explanation-3: -Cytochalasins inhibit nuclei-induced actin polymerization by blocking filament elongation.