INTRODUCTION TO MICROSCOPY CELL BIOLOGY
CYTOSKELETON
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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Which protein on a fibroblast membrane attaches to the extracellular matrix outside the cell (through adapter molecules) to actin on the inside?
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Proteoglycan
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Cadherin
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Fibronectin
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Integrin
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Explanation:
Detailed explanation-1: -Integrins are the principal receptors used by animal cells to bind to the extracellular matrix. They are heterodimers and function as transmembrane linkers between the extracellular matrix and the actin cytoskeleton.
Detailed explanation-2: -Integrins are cell-surface proteins that bind cells to ECM structures, such as fibronectin and laminin, and also to integrin proteins on the surface of other cells. Fibronectins bind to ECM macromolecules and facilitate their binding to transmembrane integrins.
Detailed explanation-3: -A network of collagen fibers and proteoglycans is found outside of the cell. Collagen connects to integrin proteins in the plasma membrane via fibronectin.
There is 1 question to complete.