MICROANATOMY

Detailed explanation-1: -Answer and Explanation: Compared to small cells, large cells have more trouble moving materials across the cellular membrane. This includes both moving needed materials in and getting rid of waste. The issue is that large cells have a lower ratio of surface area to volume.

Detailed explanation-2: -As a cell gets bigger, it has a difficult time keeping up with taking in the extra nutrients it needs and expelling more waste. In other words, as the cell gets bigger, it has less surface area compared to its size-the surface area to volume ratio of the cell decreases as it gets bigger.

Detailed explanation-3: -With smaller cells, more surface area is available for oxygen and nutrients to diffuse in and carbon dioxide to diffuse out of the cell. Thus many small cells can take up oxygen and nutrients and release carbon dioxide much more quickly than one large cell.

Detailed explanation-4: -1. The larger the cell, the more demands the cell places on its DNA. 2. The cell has trouble moving enough nutrients and wastes across the cell membrane.