MICROANATOMY

Detailed explanation-1: -Protein undergoes modifications in ER before reaching their final destination. Explanation: After the synthesis of protein, it undergoes various modifications before reaching their final destination i.e. Glycosylation, protein folding, the formation of disulfide bridges, and specific proteolytic cleavage.

Detailed explanation-2: -Following protein synthesis and translocation into the ER lumen, a protein destined for secretion must undergo proper folding and modifications, with the aid of chaperones and folding enzymes. These modifications include N-linked glycosylation, disulfide bond formation and oligomerization [3].

Detailed explanation-3: -In the RER lumen, proteins may undergo slight modifications, such as having their signal sequences cleaved or undergoing glycosylation (in which an oligosaccharide is added, producing a glycoprotein). Protein form also changes, whereby the molecule assumes its three-dimensional conformation.

Detailed explanation-4: -Thus, the correct answer is option ‘It is studded with ribosomes that form a bumpy coat’.