MICROANATOMY

Detailed explanation-1: -Lysosomes are the common terminal nexus of endocytosis, phagocytosis, autophagy and biosynthetic routes, receiving both extracellular and intracellular-derived molecular cargo, cytoplasmic cargo like damaged organelles, and engulfed dead cells and foreign particulates like bacteria for digestion (Figure 2).

Detailed explanation-2: -Lysosomes are acidic and hydrolytic organelles responsible for receiving and digesting cargo acquired during endocytosis, phagocytosis, and autophagy. For macrophages and dendritic cells, the lysosome is kingpin, playing a direct role in microbe killing and antigen processing for presentation.

Detailed explanation-3: -Lysosomes can degrade materials delivered to them by way of biosynthetic transport, endocytosis, phagocytosis and autophagy. Because of their prominent role in intracellular degradation, lysosomes have earned a reputation as the ‘garbage disposal system’ of the cell.