INTRODUCTION TO MICROSCOPY CELL BIOLOGY
MITOCHONDRIA
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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cristae
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matrix
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inner membrane
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outer membrane
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Detailed explanation-1: -Pyruvate crosses the outer mitochondrial membrane (OMM) probably via the VDAC into the intermembrane space (IMS). Pyruvate is then transported across the IMM by the MPC. It has also been suggested that the MPC transports ketone bodies across the IMM.
Detailed explanation-2: -Outer membrane – the outer membrane contains transport proteins that enable the shuttling of pyruvate from the cytosol.
Detailed explanation-3: -In aerobic conditions, pyruvate is primarily transported into the mitochondrial matrix and converted to acetyl-coenzyme A (acetyl-CoA) and carbon dioxide by the pyruvate dehydrogenase complex (PDC).
Detailed explanation-4: -The transport of pyruvate into mitochondria depends on the proton-motive force across the inner mitochondrial membrane.