MICROANATOMY

Detailed explanation-1: -The three-carbon pyruvic acid molecules are converted to a two-carbon molecule attached to Coenzyme A, called acetyl CoA, via the process of pyruvate oxidation . It is the product, acetyl CoA, which enters the Krebs cycle.

Detailed explanation-2: -The acetyl-CoA thus formed combines with oxaloacetic acid to form citric acid in first step of the krebs cycle.

Detailed explanation-3: -So, for every 1 pyruvate molecule added, the Krebs cycle will produce: 2 molecules of CO. 3 molecules of NADH. 1 molecule of FADH.

Detailed explanation-4: -The molecule “feeding” the citric acid cycle is acetyl-CoA and it can be obtained from pyruvate (from glycolysis), from fatty acid -oxidation, from ketone bodies, and from amino acid metabolism. Molecules from other pathways feeding into the citric acid cycle for catabolism make the citric acid cycle ‘cataplerotic’.