MICROANATOMY

Detailed explanation-1: -The epiphyseal plate is the area of elongation in a long bone. It includes a layer of hyaline cartilage where ossification can continue to occur in immature bones.

Detailed explanation-2: -The epiphyseal plate is the area of growth in a long bone. It is a layer of hyaline cartilage where ossification occurs in immature bones. On the epiphyseal side of the epiphyseal plate, cartilage is formed.

Detailed explanation-3: -Endochondral Ossification This process involves the replacement of hyaline cartilage with bone. It begins when mesoderm-derived mesenchymal cells differentiate into chondrocytes.

Detailed explanation-4: -As an individual reaches the end of the overall growth period, caused by increased concentrations of sex steroid hormones during puberty, the cartilage of the epiphyseal plate diminishes and is finally replaced by bone to form the epiphyseal line.

Detailed explanation-5: -The epiphyseal growth plate is the main site of longitudinal growth of the long bones. At this site, cartilage is formed by the proliferation and hypertrophy of cells and synthesis of the typical extracellular matrix. The formed cartilage is then calcified, degraded, and replaced by osseous tissue.