MICROANATOMY

Detailed explanation-1: -Also known as cortical bone, it’s tightly packed tissue with a connective extracellular matrix with no gaps that makes up the wall of the diaphysis. A hollow chamber formed in compact bone in the diaphysis of a long bone that is continuous with the spaces of the spongy bone.

Detailed explanation-2: -The ECM is a non-cellular three-dimensional structure secreted by cells into the extracellular space. It is composed of specific proteins and polysaccharides. The ECM of each tissue type has a unique composition and topology during development (Frantz et al., 2010).

Detailed explanation-3: -Compact bone consists of closely packed osteons or haversian systems. The osteon consists of a central canal called the osteonic (haversian) canal, which is surrounded by concentric rings (lamellae) of matrix.

Detailed explanation-4: -Bone consists of a highly calcified, extracellular bone matrix, and cells (Fig. 1). Bone matrix (also known as osteoid) consists of about 33% organic matter (mostly Type I collagen) and 67% inorganic matter (calcium phosphate, mostly hydroxyapatite crystals).