MICROANATOMY

Detailed explanation-1: -The osteoblasts secrete the organic matrix, which are dense collagen layers that alternate parallel and orthogonal to the axis of stress loading. Into this matrix is deposited extremely dense hydroxyapatite-based mineral driven by both active and passive transport and pH control.

Detailed explanation-2: -Osteoblasts (Ob) secrete collagenous (Col1) and noncollagenous proteins such as osteocalcin (OCN), osteopontin (OSP), osteonectin (OSN), bone sialoprotein (BSP), and bone morphogenetic proteins (BMP). Osteocytes (Ot) are located within lacunae surrounded by mineralized bone matrix (B).

Detailed explanation-3: -Osteoblasts secrete a range of proteins: Type 1 collagen, osteocalcin, osteonectin and osteopontin.

Detailed explanation-4: -Osteoblasts are the cells which secrete the bone matrix. They are typically of an ovoid shape, with slender cytoplasmic processes extending from them into contact with those of adjacent cells.

Detailed explanation-5: -Bone tissue is a specialized connective tissue composed of organic and inorganic fractions. The organic fraction consists of specialized bone cells, including osteoclasts, osteoblasts, and osteocytes, and of an extracellular matrix mainly composed of type I collagen, osteopontin, osteocalcin, and proteoglycans.