MICROANATOMY

Detailed explanation-1: -Osteoclasts also participate in the long-term maintenance of blood calcium homeostasis. During bone resorption, the osteoclasts resorb the bone surface forming depressions known as Howship’s lacunae.

Detailed explanation-2: -Bone Resorption: Osteoclast Action and Proteolytic Enzymes. Bone resorption involves both dissolution of bone mineral and degradation of organic bone matrix. Osteoclasts are highly specialized to perform both of these functions.

Detailed explanation-3: -Osteoclasts are the cells that degrade bone to initiate normal bone remodeling and mediate bone loss in pathologic conditions by increasing their resorptive activity. They are derived from precursors in the myeloid/monocyte lineage that circulate in the blood after their formation in the bone marrow.

Detailed explanation-4: -The osteoclast then attaches itself to the surface of the bone, with the sealing zone forming an isolated microenvironment. The ruffled membrane then secretes hydrochloric acid to dissolve the bone material, and the demineralized bone matrix is broken down by enzymes cathepsin K and matrix metalloprotease.

Detailed explanation-5: -Bone tissue is continuously remodeled through the concerted actions of bone cells, which include bone resorption by osteoclasts and bone formation by osteoblasts, whereas osteocytes act as mechanosensors and orchestrators of the bone remodeling process.