MICROANATOMY

Detailed explanation-1: -Bone remodeling is a highly complex process by which old bone is replaced by new bone, in a cycle comprised of three phases: (1) initiation of bone resorption by osteoclasts, (2) the transition (or reversal period) from resorption to new bone formation, and (3) the bone formation by osteoblasts [10, 11].

Detailed explanation-2: -Bone remodeling (or bone metabolism) is a lifelong process where mature bone tissue is removed from the skeleton (a process called bone resorption) and new bone tissue is formed (a process called ossification or new bone formation).

Detailed explanation-3: -The skeleton is a metabolically active organ that undergoes continuous remodeling throughout life.

Detailed explanation-4: -The osteoclasts remove bone by dissolving the mineral and breaking down the matrix in a process that is called bone resorption.