MICROANATOMY

Detailed explanation-1: -Endochondral ossification involves the replacement of hyaline cartilage with bony tissue. Most of the bones of the skeleton are formed in this manner. These bones are called endochondral bones. In this process, the future bones are first formed as hyaline cartilage models.

Detailed explanation-2: -Endochondral ossification is the mechanism responsible for the formation of all long bones of the axial skeleton (vertebrae and ribs) and the appendicular skeleton (limbs).

Detailed explanation-3: -The process by which a cartilage intermediate is formed and replaced by bone cells is called endochondral ossification.

Detailed explanation-4: -During endochondral ossification, an avascular tissue (cartilage) is gradually converted into one of the most highly vascularized tissues in the vertebrate body (bone). This conversion is dependent upon an angiogenic switch along the growth plate.

Detailed explanation-5: -Endochondral ossification can be divided into five stages: commitment, compaction, proliferation, growth, and finally, chondrocyte death and the generation of new bone.