MICROANATOMY

Detailed explanation-1: -The common ancestor for osteoblasts in both the endochondral and the intramembranous ossification are mesenchymal stromal cells (MSCs), also referred to as mesenchymal stem cells due to their multipotency. These cells can give rise either to myoblast, osteoblast, chondrocyte, or adipocyte lineages [7] (Figure 1, top).

Detailed explanation-2: -Osteoblasts. Osteoblasts are cuboidal cells that are located along the bone surface comprising 4–6% of the total resident bone cells and are largely known for their bone forming function [22].

Detailed explanation-3: -Osteoblasts are cells responsible for the secretion and deposition of bone morphogenetic proteins (BMPs) into the extracellular matrix during bone formation.

Detailed explanation-4: -Under normal physiological conditions osteoblasts are responsible for the formation of new bone in the developing skeleton and during the process of bone remodelling.