MICROANATOMY

Detailed explanation-1: -Osteoblasts and osteoclasts are special cells that help your bones grow and develop. Osteoblasts form new bones and add growth to existing bone tissue. Osteoclasts dissolve old and damaged bone tissue so it can be replaced with new, healthier cells created by osteoblasts.

Detailed explanation-2: -Bone is an active living tissue that is constantly being renewed through a process known as remodelling. Cells called osteoclasts break down old, damaged bone to make way for new bone laid down by cells called osteoblasts.

Detailed explanation-3: -Osteoclasts are the cells that degrade bone to initiate normal bone remodeling and mediate bone loss in pathologic conditions by increasing their resorptive activity.

Detailed explanation-4: -Osteoclasts dissolve bone mineral by massive acid secretion and secrete specialized proteinases that degrade the organic matrix, mainly type I collagen, in this acidic milieu.

Detailed explanation-5: -Osteoclasts are responsible for aged bone resorption and osteoblasts are responsible for new bone formation (Matsuoka et al., 2014). The resorption and formation is in stable at physiological conditions.