MICROANATOMY

Detailed explanation-1: -The cell responsible for bone resorption, or breakdown, is the osteoclast, which is found on bone surfaces, is multinucleated, and originates from monocytes and macrophages (two types of white blood cells) rather than from osteogenic cells.

Detailed explanation-2: -Osteoclasts are large multinucleated cells whose function is to resorb bone. Osteoclasts dissolve the matrix and osteoid with acids and hydrolytic enzymes. Osteoclasts are phagocytic and are derived from monocytes and not from the same line as the other bone cells.

Detailed explanation-3: -Osteoclasts are the cells that degrade bone to initiate normal bone remodeling and mediate bone loss in pathologic conditions by increasing their resorptive activity.

Detailed explanation-4: -The osteoclast: a multinucleated, hematopoietic-origin, bone-resorbing osteoimmune cell.

Detailed explanation-5: -Osteoclast Basics and Histology Osteoclasts are specialized multinucleated giant cells that resorb bone. This is carried out primarily due to remodeling of extracellular matrix. Osteoclasts are derived from monocyte fusion and have from about 2 to 12 nuclei per cell.