MICROANATOMY

Detailed explanation-1: -As the secreted matrix surrounding the osteoblast calcifies, the osteoblast becomes trapped within it. As a result, it changes in structure, becoming an osteocyte, the primary cell of mature bone and the most common type of bone cell. Each osteocyte is located in a space (lacuna) surrounded by bone tissue.

Detailed explanation-2: -Osteoblasts produce many substances including growth factors, collagenase, osteocalcin, alkaline phosphatase and collagen. The bone matrix eventually grows to surround osteoblasts and the bone material becomes calcified. Once surrounded and trapped, the osteoblast becomes a mature bone cell referred to as an osteocyte.

Detailed explanation-3: -Osteoblast to Osteocyte Transition At the end of the bone formation phase, osteoblasts can either become embedded in bone as osteocytes, become inactive osteoblasts or bone lining cells3 or undergo programmed cell death (apoptosis)3, 4.

Detailed explanation-4: -Osteoblasts migrate to the membranes and deposit bony matrix around themselves. When the osteoblasts are surrounded by matrix they are called osteocytes.

Detailed explanation-5: -In most cases, osteoblasts are separated from the region of calcification by a layer of the osteoid matrix they secrete. Occasionally, though, osteoblasts become trapped in the calcified matrix and become osteocytes-bone cells.