MICROANATOMY

Detailed explanation-1: -PTH stimulates bone formation as well as resorption.

Detailed explanation-2: -Parathyroid hormone (PTH) paradoxically causes net bone loss (resorption) when administered in a continuous fashion, and net bone formation (deposition) when administered intermittently.

Detailed explanation-3: -Calcitonin increases Wnt10b and bone formation but decreases bone resorption in ovariectomized osteoporotic rats.

Detailed explanation-4: -Calcitonin inhibits (blocks) the activity of osteoclasts, which are cells that break down bone. When osteoclasts break down your bone, the calcium from your bone is released into your bloodstream. Therefore, the temporary blocking of osteoclasts by calcitonin reduces the amount of calcium that enters your blood.