MUSCLE NERVE CARTILAGE BONE
GANGLIA
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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In Parkinson’s disease, the defect is in the ____ leading to decreased dopamine available at the striatum and results in overactivity of the ____ .
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Thalamus; direct pathway
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Subthalamic nucleus; indirect pathway
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Globus pallidus; direct pathway
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Substantia nigra; indirect pathway
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Explanation:
Detailed explanation-1: -Dopaminergic pathway is the most disrupted pathway in the pathogenesis of Parkinson’s disease. Several studies reported associations of dopaminergic genes with the occurrence of adverse events of dopaminergic treatment. However, none of these studies adopted a pathway based approach.
Detailed explanation-2: -Parkinson’s disease develops when the neurons connecting the substantia nigra to the striatum die, cutting off a critical dopamine source; in a process that is not entirely understood, too little dopamine translates to difficulty initiating movement.
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