MICROANATOMY

Detailed explanation-1: -The basal ganglia are situated at the base of the forebrain and top of the midbrain. Basal ganglia are strongly interconnected with the cerebral cortex, thalamus, and brainstem, as well as several other brain areas.

Detailed explanation-2: -Loss of dopaminergic neurons in Parkinson’s disease causes pallor of the substantia nigra which can be seen at post-mortem examination. The lateral part of the substantia nigra (which projects to the putamen or ‘motor striatum’) is more severely affected than the medial portion (which projects to the caudate nucleus).