MICROANATOMY

Detailed explanation-1: -Although glutamate is the most common neurotransmitter here as everywhere in the brain, the inhibitory neurotransmitter GABA plays the most important role in the basal ganglia.

Detailed explanation-2: -gamma-Aminobutyric acid type A (GABA(A)) receptors, the major inhibitory neurotransmitter receptors responsible for fast inhibition in the basal ganglia, belong to the superfamily of “cys-cys loop” ligand-gated ion channels.

Detailed explanation-3: -This pathway projects from the substantia nigra pars compacta to the striatum, and it utilizes the neurotransmitter dopamine. This pathway has a modulatory effect on the basal ganglia, with dopamine facilitating the motor loop in these two ways: It excites the direct pathway.