MICROANATOMY

Detailed explanation-1: -Specifically, the inside of the cell has a negative charge just inside the cell membrane, with a higher concentration of Potassium ions inside the cell; the outside of the cell has a postive charge, with a higher concentration of Sodium ions.

Detailed explanation-2: -The correct answer: For nerve and muscle cells, the inside of the cell is negatively-charged relative to the outside. In the nerve and muscle cells, there are potassium ions inside the cells and sodium ions present outside the cells.

Detailed explanation-3: -Before stimulation, a neuron or muscle cell has a slightly negative electric polarization; that is, its interior has a negative charge compared with the extracellular fluid.

Detailed explanation-4: -A neuron at rest is negatively charged: the inside of a cell is approximately 70 millivolts more negative than the outside (−70 mV, note that this number varies by neuron type and by species).

Detailed explanation-5: -What generates the resting membrane potential is the K+ that leaks from the inside of the cell to the outside via leak K+ channels and generates a negative charge in the inside of the membrane vs the outside. At rest, the membrane is impermeable to Na+, as all of the Na+ channels are closed.