MICROANATOMY

Detailed explanation-1: -Acute poliomyelitis is a disease of the anterior horn motor neurons of the spinal cord and brain stem caused by poliovirus. Flaccid asymmetrical weakness and muscle atrophy are the hallmarks of its clinical manifestations, due to loss of motor neurons and denervation of their associated skeletal muscles.

Detailed explanation-2: -Most often, polio survivors start to experience gradual weakening in muscles that were previously affected by the polio infection. Some people may have minor symptoms while others develop visible muscle weakness and atrophy (wasting away).

Detailed explanation-3: -Paralysis is the most severe symptom associated with poliovirus because it can lead to permanent disability and death. Between 2 and 10 out of 100 people who have paralysis from poliovirus infection die, because the virus affects the muscles that help them breathe.

Detailed explanation-4: -The muscle most frequently paralysed was the deltoid. When complete paralysis of the whole deltoid occurred and was associated with paralysis of the rotator cuff muscles, the shoulder often subluxed downwards. The next most commonly affected muscles were the elbow flexors and extensors.

Detailed explanation-5: -Polio is a fast spreading viral infection, with no symptoms in most cases. One in 200 infections leads to irreversible paralysis (usually in the legs).