MICROANATOMY

Detailed explanation-1: -The thick filaments of muscle consist of several hundred myosin molecules, associated in a parallel staggered array by interactions between their tails (Figure 11.23). The globular heads of myosin bind actin, forming cross-bridges between the thick and thin filaments.

Detailed explanation-2: -In striated muscle cells, myosin forms the backbone of the thick filaments, which are anchored within the M-band and extend bidirectionally toward the two opposite ends of the sarcomere (171, 247).

Detailed explanation-3: -The myofibrils are made up of thick and thin myofilaments, which help give the muscle its striped appearance. The thick filaments are composed of myosin, and the thin filaments are predominantly actin, along with two other muscle proteins, tropomyosin and troponin.

Detailed explanation-4: -Thick filaments are composed of dimers of a remarkable force-generating protein called myosin. Allmyosin molecules have helical tails and globular head groups that hydrolyze ATP and act as motors to move along an actin filament.