MICROANATOMY

MUSCLE NERVE CARTILAGE BONE

SKELETAL MUSCLE

Question [CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
Which muscle protein is thick and which is thin?
A
Sarcomere is thick and Actin is thin
B
Myosin is thick and Titin is thin
C
Myosin is thick and Actin is thin
D
Titin is thick and Sarcomere is thin
Explanation: 

Detailed explanation-1: -The I bands contain only thin (actin) filaments, whereas the A bands contain thick (myosin) filaments.

Detailed explanation-2: -The thin filaments contain actin, tropomyosin, troponins C, I, and T and nebulin. The thick filaments are composed of myosin with the globular heads forming cross-bridges with thin filaments. Myosin-binding proteins, including MyBP-C, are associated with the thick filaments.

Detailed explanation-3: -Myosin, the back-bone of the thick filament, slides past actin thin filaments by hydrolyzing adenosine triphosphate (ATP) to mediate muscle contraction (255, 256).

Detailed explanation-4: -An individual sarcomere contains many parallel actin (thin) and myosin (thick) filaments.

Detailed explanation-5: -Thick and thin filaments, which comprise the myofilaments, are composed primarily of the proteins myosin and actin, respectively, and the light band of the sarcomere is the portion where only thin filaments are present and the dark band is where both thick and thin filaments are present.

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